〔Abstract〕 Objective To investigate the effect of propofol combined with the remifentanil on recovery time of spontaneous breathing in patients with cerebral hemorrhage after operation. Methods A total of 90 cerebral hemorrhage patients admitted to Jiamusi Central Hospital from January 2019 to October 2020 were selected as the research objects, and divided into a control group and an observation group according to different treatment regimens, with 45 patients in each group. The control group was anesthetized with propofol combined with fentanyl, and the observation group was anesthetized with propofol combined with remifentanil. The dosage of propofol, recovery time of spontaneous breathing and recovery time of patients in the two groups were evaluated, and the occurrence of adverse reactions in the two groups were compared. Results During the operation, the dosage of propofol in the observation group was less than that in the control group, and the recovery time of spontaneous breathing and recovery time of patients after the operation were shorter than those in the control group, with statistically significant differences (P < 0.05). During and after surgery, the total incidence of adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P < 0.05). Conclusion Propofol combined with remifentanil has significantly better recovery time of spontaneous breathing in patients with intracerebral hemorrhage than fentanyl combined with propofol, with rapid effect and fewer clinical adverse reactions.