〔Abstract〕 Objective To investigate the effects of amlodipine combined with atorvastatin on lipid metabolism, cardiac function and immunoglobulin (Ig) in patients with hypertension complicated with coronary heart disease (CHD). Methods A total of 96 confirmed with hypertension and CHD patients in the First Affiliated Hospital of Henan University of Science and Technology from January 2019 to January 2021 were divided into an observation group and a control group by simple random grouping method, 48 cases in each group. The control group was treated with amlodipine, and the observation group was treated with amlodipine combined with atorvastatin. Both groups were treated for 1 month. Blood lipid indexes, cardiac function and Ig were detected before and after treatment, and the incidence of adverse reactions in the two groups during treatment was recorded. Results After treatment, the total cholesterol (TC), tricylglycerol (TG), systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the two groups were decreased to varying degrees, and the TC, TG, SBP and DBP in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). After treatment, IgA, IgG and IgM in the observation group were lower than those before treatment, and IgA, IgG and IgM in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). Both groups after treatment in patients with left ventricular end-diastolic diameter (LVEDD) was lower than before treatment, left ventricular ejection fraction (LVEF) output, stroke volume (SV), mitral valve blood flow spectrum [(early ventricular diastolic blood flow velocity of the maximum blood flow velocity/atrial contraction (E/A)] levels were higher than before the treatment, and the observation group of patients after treatment of LVEDD was lower than the that in the control group, LVEF, SV and E/A were significantly higher than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Amlodipine combined with atorvastatin has a good therapeutic effect on lipid metabolism, cardiac function and Ig regulation in patients with hypertension complicated with coronary heart disease.