〔Abstract〕 Objective To study the clinical value of non-invasive sputum suction combined with atomization inhalation in the treatment of children with bronchiolitis. Methods A total of 146 children with bronchiolitis admitted to Luoyang Maternal and Child Health Hospital from September 2019 to June 2020 were selected and divided into an observation group and a control group according to random number table method, with 73 cases in each group. The control group was treated with atomization inhalation, and the observation group was treated with non-invasive sputum suction for 2 weeks. The curative effect of the two groups was compared, the changes of respiratory function of the children before and after treatment were detected, and the improvement of symptoms was observed. Results Cough relief time, fever relief time, gasp disappearance time, tachypnea improvement time, pulmonary rales disappearance time, daily sputum aspiration times, hospital stay time in the observation group were shorter than those of the control group, the differences were statistically significant (P < 0.05). The peak expiratory flow (PEF) of the observation group was higher than that of the control group 30 min after intervention, and the difference was statistically significant (P < 0.05). After treatment, blood oxygen saturation and respiration rate of the two groups were higher than those of the control group, while heart rate was lower than that of the control group, with statistical significances (P < 0.05). The total effective rate of the observation group was 93.16%, higher than 75.34% of the control group, the difference was statistically significant (P < 0.05). Conclusion Non-invasive sputum suction combined with aerosol inhalation in the treatment of bronchiolitis in children is better than the single treatment method. It can improve airway obstruction, relieve symptoms of wheezing, and reduce hospital stay, and the operation is simple and safe.