〔Abstract〕 Objective To investigate the therapeutic effect of family participatory long-term management in the treatment of children epilepsy. Methods A total of 94 children with epilepsy and language impairment treated in the First Affiliated Hospital of Henan University of Science and Technology from October 2019 to December 2020 were randomly divided into a control group and an observation group, with 47 cases in each group. The children in the control group were given speech training therapy on the basis of conventional antiepileptic drug therapy, and the children in the observation group were given family participatory long_x005fterm management therapy on the basis of treatment in the control group. The clinical efficacy and medication compliance of the two groups were compared after 6 months of treatment. Wechsler Child Intelligence Scale (WISC-IV) and Wechsler Memory Scale (WMS) were used to compare the intelligence level and memory ability of the two groups before and after treatment. Results The total effective rate of the observation group was 76.60%, which was higher than 57.45% of the control group, and the difference was statistically significant (P < 0.05). The compliance rate of the observation group was 95.74% after 6 months of treatment, which was higher than 82.98% of the control group, and the difference was statistically significant (P < 0.05). After 6 months of treatment, the total intelligence quotient (IQ) and total memory quotient of the two groups were higher than those before treatment, and the total IQ and total memory quotient of the observation group were higher than those of the control group, the differences were statistically significant (P < 0.05). Conclusion Family participatory long-term management has a better therapeutic effect on children with epilepsy and language impairment, which can effectively improve their medication compliance and facilitate their development of intelligence and memory.