〔Abstract〕 Objective To compare the effects of drospirone ethinylestradiol tablet (Ⅱ), deoxygestrel ethinylestradiol tablet and levonorgestrel intrauterine contraceptive system on Ki-67 expression and hormone level after endometrial polyp (EP). Methods A total of 150 patients with EP who received treatment in Luoyang Maternal and Child Health Hospital from March 2019 to October 2020 were selected and divided into group A [drospirenone ethoestradiol tablet (Ⅱ)], group B (deoxygestrel ethoestradiol tablet) and group C (levonorgestrel intrauterine contraception system) according to different postoperative treatment plans, with 50 patients in each group. The postoperative treatment effect, Ki-67 expression and sex hormone levels were compared among the three groups. Results The recurrence rate of group C at 6 and 12 months after surgery was significantly lower than that of the group A and group B, the difference was statistically significant (P < 0.05). The endometrial thickness of group C was thinner than that of the group A and group B at 3 months, 6 months and 12 months after surgery, with statistical significance (P < 0.05). 6 months after operation, the proportion of grade 3 expression of endometrium Ki-67 in group C was lower than that in the group A and group B, and the proportion of estrogen receptor (ER) and progesterone receptor (PR) grade 3 patients was significantly higher than that in group A and group B, with statistical significance (P < 0.05). Conclusion The application effect of levonorgestrel intrauterine contraceptive system after EP and the effect on Ki-67 expression and hormone level were obviously better than the drospirone ethinylestradiol tablets (Ⅱ) and deoxygestrel ethinylestradiol tablets.