〔Abstract〕 Objective To investigate the clinical effect of Tonglin Paishi decoction in the treatment of patients with kidney stones after percutaneous nephrolithotomy. Methods A total of 76 patients with kidney stones of Qi stagnation and blood stasis type diagnosed in Xinzheng Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected and randomly divided into an observation group and a control group, with 38 cases in each group. The control group was treated with percutaneous nephrolithotomy, and the observation group was treated with Tonglin Paishi decoction on the basis of the treatment of the control group for 14 days. The changes of urinalgia, dyspuria and colic syndrome scores before and after treatment and clinical efficacy evaluation after treatment were compared between the two groups. Renal function indexes of patients were detected, and the occurrence of adverse reactions during treatment were recorded. Results The total effective rate of the observation group was 92.11%, which was higher than 78.95% of the control group, and the difference was statistically significant (P < 0.05). After treatment, the scores of dysuria, dyspuria and colic in the two groups were lower than those of before treatments, and the scores of the observation group were lower than those of the control group, the differences were statistically significant (P < 0.05). After treatment, there was no significant difference in serum creatinine (SCr) and urea nitrogen (BUN) between the two groups (P > 0.05). The total incidence of adverse reactions in the observation group was 5.26%, which was lower than 7.86% in the control group, and the difference was not statistically significant (P > 0.05). Conclusion The adjuvant treatment of Tonglin Paishi decoction can significantly improve the clinical symptoms of residual stones and stone removal rate after percutaneous nephrolithotripsis.