〔Abstract〕 Objective To compare the effects of micro implant anchorage and extraoral arch reinforcement anchorage in orthodontic treatment of patients with static periodontitis. Methods 400 patients with static periodontitis treated in the Central Hospital of Jiaozuo Coal Industry Group Co. Ltd from January 2018 to December 2020 were randomly divided into control group and observation group, with 200 cases in each group. The control group was treated with extraoral arch reinforcement anchorage, and the observation group was treated with micro implant anchorage. The therapeutic effect and adverse reactions of the two groups were evaluated, and the changes of maxillary and mandibular angle of X-ray projection and the level of inflammatory factors were compared between the two groups before and after treatment. Results The total effective rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (P < 0.05). After treatment, sella– nasion–B (SNB), salla–nasion–A (SNA), A–point–nasion–B (ANB), formation angle between mandibular first molar and mandibular surface (L6-MP), mandibular central incisor-mandibular plane angle (L1-MP), upper central incisor-anterior skull base plane angle (U1-SN), the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) of the observation group were significantly better than those of the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Compared with extraoral arch reinforcement anchorage, micro implant anchorage is more helpful to improve the orthodontic effect, reduce the level of inflammatory factors and reduce the incidence of adverse reactions in patients with static periodontitis.