〔Abstract〕 Objective To investigate the effect of transcutaneous electrical stimulation of trigeminal nerve and hyperbaric oxygen on coma after cerebral apoplexy or craniocerebral injury. Methods 60 patients with stroke or traumatic brain injury coma patients in Jiaoling County People's Hospital from June 2016 to December 2019 were selected as research objects, and randomly divided into control group and observation group, 30 cases in each group. Both groups of patients were given conventional conservative treatment and hyperbaric oxygen therapy, the observation group with transcutaneous trigeminal nerve electrical stimulation and hyperbaric oxygen therapy, the awake time, awake rate, and Glasgow outcome scale (GOS) grading after 6 months of treatment were compared between the two groups. Results The observation group had shorter waking time and higher waking rate than those of the control group, the differences were statistically significant (P < 0.05), after treatment the GOS grading of the observation group was better than that of the control group (Z = 0.633, P < 0.05). Conclusion Transcutaneous trigeminal nerve electrical stimulation and hyperbaric oxygen have better effect on the poctients in coma after cerebral apoplexy or craniocerebral injury.