〔Abstract〕 Objective To observe the curative effect of Yupingping granule assisted with levcetirizine and desloredatadine in the treatment of chronic urticaria (CU) and its effect on immune function and inflammatory state. Methods A total of 150 CU patients admitted to Central People's Hospital of Zhanjiang from January 2019 to December 2020 were selected and divided into three groups, A, B and C, with 50 patients in each group according to their voluntary treatment methods. Group A was treated with levcetirizine and loratadine in combination, group B was treated with levcetirizine and loratadine in turn, and group C was treated with Yupingfeng granule on the basis of group B. The total effective rates of the three groups were recorded, the levels of inflammatory factors and immune function indexes of the three groups were detected before and after treatment, and the rates of adverse reactions in the three groups were observed and recorded. Results The total effective rate in group C was higher than those in group A and group B, and the differences were statistically significant (P < 0.05). There was no significant difference between group A and group B (P > 0.05). Before treatment, there was no significant difference in the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4) and leukotriene D4 (LTD4) among three groups (P > 0.05). After treatment, the levels of IL-4, LTD4 and IgE in group C were lower than those in group A and group B, and the differences were statistically significant (P < 0.05). Before treatment there was no significant difference in CD3+ , CD4+ and CD8+ among the three groups of patients (P > 0.05). After treatment, the levels of CD3+ and CD4+ in group C were higher than those in group A and B, while the levels of CD8+ were lower than those in group A and B, the differences were statistically significant (P < 0.05). There was no significant difference in the rate of adverse reactions among the three groups (P > 0.05). Conclusion Yupingfeng granule assisted with levcetirizine and desloratadine in rotation treatment of CU has outstanding clinical effect, which can improve inflammatory response, improve immune function, and does not increase the risk of adverse reactions.