〔Abstract〕 Objective To evaluate the application effect of traditional Chinese medicine (TCM) and Maintenance Management System in the maintenance and management of TCM decoction pieces in Peking University Shenzhen Hospital. Methods TCM maintenance management data and inspection data of quality control team before and after the application of the software in Peking University Shenzhen Hospital were collected, and the monthly number of decoction piece maintenance varieties, maintenance working time, the number of unqualified decoction pieces in the pharmacy self-inspection during the maintenance period, and annual complaints of patients on the quality of decoction pieces were compared before and after the implementation of the software. Results After the implementation of the software, the average number of prepared slices required for monthly maintenance in Shenzhen Hospital of Peking University decreased by 76.5% compared with that before the implementation, with statistical significance (P < 0.01), The number of general decoction pieces and key decoction pieces conservation varieties decreased by 79.3 % and 54.3 % respectively, with statistical significance (P < 0.01). The consumption time of monthly maintenance inspection and treatment and the detection times of unqualified decoction pieces in pharmacy decreased significantly compared with before implementation, with statistical significance (P < 0.01); The proportion of patients' annual complaints on the quality of decoction pieces in the total number of prescriptions dropped from 0.035% to 0.007%, the difference was statistically significant (P < 0.01). Conclusion The implementation of "TCM and Maintenance Management System" software not only greatly improves the work efficiency of TCM decoction pieces maintenance in Peking University Shenzhen Hospital, but also realizes the "precise maintenance" of TCM decoction pieces in Peking University Shenzhen Hospital, laying a foundation for the whole process information management of TCM pharmacy.