〔Abstract〕 Objective To observe and analyze the postoperative bleeding of patients with early gastric cancer (EGC) and precancerous lesions after endoscopic mucosal resection (EMR), and analyze the related influencing factors. Methods The clinical data of 166 patients with EGC and its precancerous lesions with EMR in the First Affiliated Hospital of Henan University of Science and Technology from October 2019 to July 2020 were retrospectively analyzed. According to the occurrence of postoperative bleeding, they were divided into 9 cases in the bleeding group and 157 cases in the non-bleeding group, and the factors influencing postoperative bleeding were analyzed by logistic regression. Results Postoperative bleeding occurred in 9 of the 166 patients, with an incidence rate of 5.42 %; There were statistically significant differences between the bleeding group and the non-bleeding group in the main lesion site, lesion diameter, number of lesions, infiltration depth and seniority of the chief surgeon in the bleeding group were significantly different from those in the non-bleeding group (P < 0.05). There was no statistically significant difference between the two groups in patient's age, gender, history of diabetes, hypertension, hyperlipidemia, medical history, family history of cancer, smoking history, drinking history, history of medicine, clopidogrel aspirin dose, metformin long-term medication history, pathological type, horizontal vertical cutting edge and cutting edge, operation time (P > 0.05); Multivariate logistic regression analysis showed that the main lesions were located in cardia to fundus of the stomach [OR = 8.240, 95% CI (2.871, 23.653)] and the number of lesions was ≥ 2 [OR = 1.692, 95% CI (2.252, 13.093)], lesion diameter ≥ 2 cm [OR = 6.713, 95% CI (2.667, 16.897)], infiltration depth to submucosa [OR = 4.067, 95%CI (1.671, 9.903)] and the operating surgeon's experience < 5 years [OR = 3.908, 95% CI (2.031, 9.521)] were independent risk factors for bleeding after EMR. Conclusion The main lesion site in patients from cardia to fundus of the stomach, the number of lesions ≥ 2, the diameter of lesions ≥ 2 cm, the infiltration depth to submucosa and the experience of the surgeon < 5 years are independent risk factors for postoperative bleeding in Patients with EGC and precancerous lesions. Attention should be paid to patients with such influencing factors and preoperative evaluation should be made. Appropriate measures should be taken when necessary to reduce the risk of bleeding and ensure patient safety