〔Abstract〕 Objective To investigate the clinical characteristics of different types of hyperlipidemia acute pancreatitis (AP). Methods 1,600 AP patients diagnosed and treated in Shenzhen Second People's Hospital from July 2015 to June 2021 were analyzed retrospectively, which divided into (1) simple triglyceride elevated AP group (TG group): TG > 1.7 mmol·L-1, TC ≤ 5.2 mmol·L-1, a total of 112 cases; (2) Triplesteride with total cholesterol elevated AP group (TG/TC group): TG > 1.7 mmol·L-1 and TC > 5.2 mmol·L-1, a total of 324 cases; (3) Pure total cholesterol elevated AP group (TC group): TC > 5.2 mm ol·L-1, TG ≤ 1.7 mmol·L-1, a total of 16 cases. (4) Non–elevated lipid AP group (Non–TG/TC group): TG ≤ 1.7 mmol·L-1 and TC ≤ 5.2 mmol·L-1, a total of 1,148 cases. The basic data, biochemical indicators and clinical characteristics were compared of each group of patients. Results Compared with non-TG/TC group, males in TG group and TG/TC group were more common, had higher body weight, had lower age, and had shorter hospital stay, with statistical significance (P < 0.05). TC group only had higher body weight, with statistical significance (P < 0.05). TG group and TG/TC group had higher TG and C-reactive protein (CRP), lower amylase (AMS), alanine aminotransferase (ALT), total bilirubin (TBIL), direct bilirubin (DBIL) and prothrombin time (PT),and higher TC in TG/TC group, the differences were statistically significant (P < 0.05). The PT, TBIL, DBIL, and D-dimer (D-D) in TC group were lower than those in the TC group, ALT was higher (P < 0.05). Moderate to severe pancreatitis patients in the TG/TC group and the TC group were more in need of blood purification treatment. Intensive care unit (ICU) admissions were higher in the TG/TC group. The incidence of liver insufficiency was lower than those in the TG group and TG/TC group, the differences were statistically significant (P < 0.05). There was no significant difference in renal insufficiency and mechanical ventilation rate among all groups (P > 0.05). Conclusion The incidence of AP with elevated lipids is high, which is common in young obese men, and TG/TC type is the most common. TG/TC type and TG type have more obvious inflammatory response, and TG/TC type and TC type have more severe disease and more common blood purification treatment, but do not increase mechanical ventilation and hospitalization costs.