〔Abstract〕Objective To analyze the clinical effect of combined intervention of misoprostol and oxytocin during cesarean section in the treatment of postoperative hemorrhage in women. Methods 100 cases of postpartum hemorrhage after cesarean section in Pingdingshan Maternal and Child Health Care Hospital from October 2018 to October 2019, were randomly selected as the research objects, and divided into two groups randomly, with 50 cases in the control group and 50 cases in the observation group. Patients in the control group were treated with misoprostol, and patients in the observation group were treated with misoprostol and oxytocin combined intervention. Bleeding volume, bleeding rate and adverse reactions such as fever, nausea, vomiting and diarrhea were recorded and compared between the two groups. Results The rate of postpartum hemorrhage in the observation group (2.00 %) was significantly lower than 14.00 % in the control group, the difference was statistically significant (P < 0.05). The amount of maternal blood loss in the observation group was lower than that in the control group at 2h after operation, and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of 4 adverse reactions including fever, nausea, vomiting and diarrhea between the two groups (P > 0.05). Conclusion In the process of caesarean section, the joint intervention of the oprotanol and oxytocin was conducive to the effective improvement of the postoperative hemorrhage of maternity surgery, and the occurrence of adverse reactions in the process of maternal treatment.