〔Abstract〕Objective To investigate the effect of zirconia restoration on chewing ability of patients in oral prosthodontics. Methods A total of 500 patients who received oral prosthodontics in Dongguan Kanghua Hospital from April 2016 to March 2020 were randomly selected and divided into a control group and an observation group according to different prosthodontics, with 250 patients in each group. The patients with traditional porcelain metal restoration were set as the control group, and the patients with zirconia restoration were set as the observation group. The chewing ability and the excellent and good treatment rate of the two groups were observed and compared. Gingival indexes (gingival index, bleeding index, plaque index) and interleukin–6 (IL–6) and interleukin–8 (IL–8) in gingival crevicular fluid were analyzed and compared between the two groups before and after treatment. Results Seven months after repair, the chewing ability score of the observation group was significantly higher than that in the control group, the gingival index, bleeding index and plaque index were better than those in the control group, the levels of IL-6 and IL-8 were lower than control group, and the good repair rate was higher than that in the control group, the differences were statistically significant between the two groups (P < 0.05). Conclusion Zirconia restorations can effectively improve the chewing ability and gingival function of patients and reduce the level of inflammatory factors, which is better than traditional porcelain metal restorations.