〔Abstract〕Objective To study and analyze the effect of Shumai Jiangya decoction combined with telmisartan in the treatment of hypertension. Methods A total of 140 hypertensive patients admitted to Xiangfu District Second People's Hospital of Kaifeng City from January 2019 to October 2019 were selected and randomly divided into a control group and an observation group, with 70 cases in each group. The control group was given telmisartan tablets, and the observation group was given shumai jiangya decoction combined with telmisartan. The treatment effects of the two groups of patients were compared. Results The total effective rate of the observation group was 90.00 %, higher than 65.71 % of the control group, the difference was statistically significant (P < 0.05). After treatment, systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). After treatment, the levels of homocysteine (Hcy), C-reactive protein (CRP) and low-density lipoprotein cholesterol (LDL-C) in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). After treatment, the scores of traditional Chinese medicine (TCM) symptoms in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). There was no difference in the incidence of adverse reactions in the observation group was 11.43%, lower than 31.43% in the control group (P > 0.05). Conclusion In the course of the treatment of hypertension, shumai jiangya decoction combined with telmisartan has a significant clinical effect.