〔Abstract〕Objective To investigate the clinical effects of Dahuang Mudan decoction combined with ceftriaxone sodium injection in the treatment of acute pelvic inflammation disease. Methods 70 patients with acute pelvic inflammation disease admitted to the Second Hospital of Nanping City from July 2019 to August 2020 were randomly divided into control group and observation group, with 35 cases in each group. The control group was treated on ceftriaxone sodium injection alone and the observation group was treated on Dahuang Mudan decoction combined with ceftriaxone sodium injection, and the level of inflammatory factors and quality of life before and after treatment and total effective rate of the two groups were compared. Results Before treatment, there was no significant difference in tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels between the two groups (P < 0.05). After treatment, the levels of TNF-α and IL-6 in the observation group were significantly lower than those in the control group (P < 0.05). There was no significant difference in quality of life score between the two groups (P < 0.05). After treatment, the quality of life score in the observation group was significantly higher than that in the control group (P < 0.05). The total effective rate of the observation group was 97.14 %, which was higher than 80.00% of the control group (P < 0.05). Conclusion Dahuang Mudan decoction combined with ceftriaxone sodium injection in the treatment of acute pelvic inflammation disease has a good effect in patients, which can beneficial to reduce the level of inflammatory factors and improve the quality of life of patients.