〔Abstract〕Objective To explore the clinical effect and feasibility of acupuncture combined with rehabilitation therapy for patients with stroke. Methods A total of 100 stroke rehabilitation patients admitted to Nanlang Hospital of Zhongshan City from March 2017 to March 2020 were selected and randomly divided into an observation group and a control group, with 50 cases in each group. The observation group was given acupuncture combined with rehabilitation therapy, while the control group was given rehabilitation therapy, the degree of neurological impairment, ability of activity of daily living (ADL), treatment effect and quality of life of the two groups were compared. Results After treatment, the National Institutes of Health Stroke Scale (NIHSS) score in the observation group was lower than that in the control group, and ADL score in the observation group was higher than that in the control group, and the differences were statistically significant (P < 0.05). The total effective rate of patients in the observation group was 98.00 %, which was higher than 74.00 % in the control group, and the difference was statistically significant (P < 0.05). After treatment, the quality of life scores of the observation group were higher than those of the control group, and the differences were statistically significant (P < 0.05). Conclusion Acupuncture combined with rehabilitation therapy in the clinical treatment of stroke patients in the rehabilitation period has significant effects on improving neurological deficits, improving self-care ability, and improving quality of life.