〔Abstract〕Objective To study the clinical value of traditional Chinese medicine sleight reduction combined with percutaneous vertebroplasty in the treatment of osteoporotic vertebral compression fracture. Methods 82 patients with osteoporotic vertebral compression fracture treated in Changde First Hospital of Traditional Chinese Medicine from July 2018 to December 2019 were divided into control group and observation group, according to odd and even grouping method, with 41 cases in each group. The control group was treated with percutaneous vertebroplasty, and the observation group was treated with traditional Chinese medicine sleight reduction combined with percutaneous vertebroplasty. The therapeutic effects and the occurrence of adverse reactions of the two groups were compared. Results The numerical rating scale (NRS) score of the observation group was lower than that of the control group 7 d after surgery, the difference was statistically significant (P < 0.05). Six months after surgery, the Cobb angle of kyphosis in both groups was reduced to varying degrees, and the anterior height of injured vertebrae was increased to varying degrees. The Cobb angle of kyphosis in the observation group was smaller than that in the control group, and the anterior height of injured vertebrae was higher than that in the control group, with statistical significance (P < 0.05). The Oswestry disability index (ODI) score in the observation group was lower than that in the control group 6 months after surgery, and the difference was statistically significant (P < 0.05). The incidence of adverse reactions in the observation group was 4.88%, lower than 12.20% in the control group, and the difference was statistically significant (P < 0.05). The operation time of single vertebral body, intraoperative fluoroscopy time and hospitalization cost in the observation group were all lower than those in the control group, with statistically significant differences (P < 0.05). There was no significant difference in the diffusion coefficient of bone cement between the observation group and the control group (P > 0.05). Conclusion Traditional Chinese medicine manual reduction combined with percutaneous vertebroplasty is safe and effective for patients with osteoporotic vertebral compression fracture.