〔Abstract〕Objective To observe the effect of auricular pressure combined with conventional western medicine on chronic heart failure and effect of cardiac function and serum inflammatory factors. Methods A total of 90 patients with chronic heart failure admitted to Henan Provincial Hospital of TCM from January 2020 to June 2021 were randomly divided into control group and observation group, with 45 cases in each group. The control group was given conventional western medicine therapy, and the observation group was given auricular pressure combined with conventional western medicine therapy. Cardiac function indexes [left ventricular myocardial mass index (LVMI), stroke volume (SV), cardiac index (CI)] were observed before and after treatment in the two groups. The contents of pro-inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interferon-γ (IFN-γ)], and anti-inflammatory factors [IL-4, IL-10, transforming growth factor-β (TGF-β)] were detected in serum. Results The total effective rate of the observation group was 97.8 %, higher than 82.2% of the control group, the difference was statistically significant (P < 0.05). After treatment, LVMI of the observation group was lower than that of the control group, SV and CI were higher than those of the control group, the differences were statistically significant (P < 0.05). After treatment, the levels of TNF-α, IL-6 and IFN-γ in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After treatment, the levels of IL-4, IL-10 and TGF-β in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). The incidence of adverse reactions was 8.9% (4/45) in the control group and 6.7% (3/45) in the observation group, with no statistical significance (P > 0.05). Conclusion Auricular pressure combined with conventional western medicine can effectively improve cardiac function and inflammatory factors in patients with chronic heart failure.