〔Abstract〕Objective To explore effect of acupoint application of traditional Chinese medicine on post operative nausea and vomiting (PONV) for the patients with painless abortion surgery. Methods 300 patients who underwent painless abortion in Guangzhou Hospital of Integrated Traditional and Western Medicine from April 2020 to September 2020 were selected and randomly divided into control group, tropisetron group and Traditional Chinese medicine sticking group, with 100 patients in each group. The control group received propofol combined with butorphanol anesthesia. Tropisetron group was injected with propofol combined with butorphanol anesthesia. On the basis of propofol combined with butorphanol anesthesia, Chinese medicine acupoint application was applied in the group of Chinese medicine application. The demographic, anesthesia and surgical characteristics of patients in each group were collected, and the postoperative nausea and vomiting within 24 h were followed up to analyze and compare the differences of the above indicators among the three groups. Results There were no significant differences in mean arterial pressure (MAP), heart rate (HR), blood oxygen saturation (SpO2) in each group before and after surgery were compared, as well as propofol dosage, anesthesia time, and operation time among the three groups were compared (P > 0.05). The incidence of PONV within 24 hours after operation was 19% in the control group, which was significantly higher than 7% in the tropisetron group and 5% in the traditional Chinese medicine sticking group, and the difference was statistically significant (P < 0.05). In the severity level of PONV, the incidence rates of grades 1 and 2 in the control group were higher than those in the tropisetron group and the traditional Chinese medicine sticking group, and the difference was statistically significant (P < 0.05). The tropisetron group and the traditional Chinese medicine sticking group were compared in the incidence and severity of PONV, and the difference was not statistically significant (P > 0.05). Conclusion Traditional Chinese medicine acupoint application can significantly reduce the incidence and severity of PONV, and can significantly improve the postoperative comfort of patients.