〔Abstract〕Objective To analyze the curative effect of minocycline hydrochloride ointment combined with tinidazole on periodontitis. Methods 76 patients with periodontitis received treatment in Stomatological Hospital of Xiamen Medical College from September 2019 to March 2021 were selected and divided into an observation group and a control group according to random number table method, with 38 cases in each group. The control group was treated with minocycline hydrochloride ointment, and the observation group was treated with minocycline hydrochloride ointment combined with tinidazole. The treatment effect, periodontitis indexes before and after treatment [gingival index (GI), tooth movement (MD), periodontal attachment level (PAL), probing depth (PD), total dental plaque index (PLI)], pain degree before and after treatment, and improvement of quality of life in the two groups were observed. Results The total effective rate in observation group was higher than that of the control group, the levels of GI, MD, PAL, PPD and PLI were lower than those of the control group, the visual analog scale (VAS) score was lower than that of the control group, and the health survey scale (SF-36) score was higher than that of the control group, the differences were statistically significant (P < 0.05). Conclusion Minocycline hydrochloride ointment combined with tinidazole can significantly improve the patients' condition, reduce their pain and improve their quality of life.