〔Abstract〕 Objective To investigate the clinical effect of invigorating spleen and strengthening kidney combined with mannan peptide capsule in the prevention and treatment of recurrent respiratory tract infection in children. Methods A total of 100 children with recurrent respiratory tract infection admitted to Pingdingshan Hospital of Traditional Chinese Medicine from May 2019 to May 2020 were randomly divided into a control group and an observation group, with 50 cases in each group. The control group was treated with mannan peptide capsule, and the observation group was treated with invigorating spleen and strengthening kidney combined with mannan peptide capsule. The changes of immune indexes and clinical symptom improvement in the two groups were observed before and after treatment. Results After treatment, the levels of immunoglobulin A (IgA), IgG and IgM in the two groups were improved to varying degrees, and the levels of IgA, IgG and IgM in the observation group were higher than those in the control group, the differences were statistically significant (P < 0.05). The total effective rate of the observation group was 96.00%, higher than 84.00% of the control group, the difference was statistically significant (P < 0.05). Conclusion In the prevention and treatment of recurrent respiratory tract infection in children, invigorating spleen and strengthening kidney combined with mannan peptide capsules can significantly improve the symptoms and improve the total effective rate of treatment.