〔Abstract〕 Objective To study the effect of microwave ablation in the treatment of hepatic hemangioma under the guidance of computed tomography (CT). Methods The research subjects were all 40 patients with hepatic hemangioma who were admitted to our hospital for treatment from September 2019 to September 2020. They were divided into a control group and an observation group by odd-even number grouping method, with 20 cases in each group. The patients in the control group were treated with conventional surgery, and the patients in the observation group were treated with CT-guided microwave ablation. The therapeutic effects of the two groups were compared. Results The total effective rate of the observation group was 90.00 %, significantly higher than 50.00 % of the control group, the difference was statistically significant (P < 0.05). There were no significant differences in liver function indexes between the two groups before treatment (P > 0.05). After treatment, the levels of glutamic oxalacetic transaminase and alanine aminotransferase levels in the observation group were lower than those in the control group, with statistical significance (P < 0.05). After treatment, the incidence of complications in the observation group was 20.00%, which was significantly lower than 65.00% in the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of direct bilirubin and total bilirubin in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion CT-guided microwave ablation for the treatment of hepatic hemangioma can achieve better clinical Results.