〔Abstract〕 Objective To analyze the effect of continuous intravenous pumping of dexmedetomidine on emergence agitation after sevoflurane mask inhalation anesthesia in children. Methods 50 children undergoing surgical operations in Shunde District Beijiao Hospital of Foshan city from July 2018 to June 2020 were selected and divided into observation group and control group with 25 cases in each group. The control group received continuous intravenous pumping of 0.9% sodium chloride injection, and the observation group received continuous intravenous pumping of dexmedetomidine. The heart rate (HR), mean arterial pressure (MAP), pediatric anesthesia emergence delirium (PAED) score, postoperative time indicators, and adverse reactions were compared between the two groups. Results HR, MAP and PAED score in the observation group were significantly lower than those in the control group, the differences were statistically significant (P < 0.05). The awakening time, extubation time and postanesthesia care unit (PACU) time of the observation group were significantly shorter than those of the control group, with statistical significance (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). Conclusion Continuous pumping with dexmedetomidine can effectively reduce the incidence of agitation after sevoflurane anesthesia in children, shorten the cupping time, and improve the safety of treatment for children.