〔Abstract〕 ObjectiveTo investigate the clinical effect of high-throughput hemodialysis in uremia patients with with chronic renal failure. Methods A total of 68 uremia patients with chronic renal failure admitted to Yangchun Hospital of Traditional Chinese Medicine from January 2020 to January 2021 were selected as the research objects, and were randomly divided into control group and observation group, with 34 cases in each group, according to the number table method. The control group received routine flux hemodialysis, and the observation group received high-throughput hemodialysis. The renal function indexes, inflammatory factor levels, blood phosphorus (P) levels, β2-microglobulin (β2-MG) levels, and the incidence of complications were compared between the two groups before and after treatment. Results A total of 68 uremia patients with chronic renal failure admitted to Yangchun Hospital of Traditional Chinese Medicine from January 2020 to January 2021 were selected as the research objects, and were randomly divided into control group and observation group, with 34 cases in each group, according to the number table method. The control group received routine flux hemodialysis, and the observation group received high-throughput hemodialysis. The renal function indexes, inflammatory factor levels, blood phosphorus (P) levels, β2-microglobulin (β2-MG) levels, and the incidence of complications were compared between the two groups before and after treatment. Conclusion High-throughput hemodialysis treatment in uremia patients with chronic renal failure can effectively improve their impaired renal function, correct inflammatory factor levels, and have high treatment safety.