〔Abstract〕 ObjectiveTo analyze the influence of interventional treatment of gestational diabetes on pregnancy outcome. Methods 150 cases of gestational diabetes patients admitted to the Third Affiliated Hospital of Guangdong Medical University from January 2015 to June 2019 were randomly divided into general intervention group and comprehensive intervention group, with 75 cases in each group, and the general intervention group was given routine diet intervention, the comprehensive intervention group added exercise management and drug control on the basis of the general intervention group, and compared the time of well blood glucose control, the results of blood glucose control before and after treatment, the body mass index, the occurrence of complications, and the perinatal adverse conditions of the two groups. Results The time of well blood glucose control in the comprehensive intervention group was shorter than that in the general intervention group, the difference was statistically significant (P < 0.05). Before treatment, there was no significant differences of fasting blood glucose, 2 h postprandial blood glucose and body mass index between the two groups of patients (P > 0.05); After treatment, the fasting blood glucose, 2 h postprandial blood glucose and body mass index of the patients in the comprehensive intervention group were all Significantly lower than the general intervention group, data testing showed significant differences (P < 0.05); The complication rate of patients in the comprehensive intervention group was 10.67%, which was significantly lower than 32.00% of the general intervention group, data testing showed significant differences (P < 0.05); The incidence of perinatal adverse events in the comprehensive intervention group was 9.33%, which was lower than 32.00% in the general intervention group. Data testing showed a significant difference (P < 0.05). Conclusion Adding exercise management and drug control on the basis of diet intervention can better control the body mass and blood sugar of patients with gestational diabetes and improve pregnancy outcome.