〔Abstract〕 Objective To investigate the clinical effect of felodipine combined with captopril in patients with chronic congestive heart failure (CHF). Methods A total of 120 patients with CHF admitted to the Fifth Hospital of Xiamen from September 2018 to September 2020 were selected and divided into observation group and control group, with 60 cases in each group, according to different treatment regimens. Both groups were given conventional treatment, on the basis of conventional treatment, the control group was treated with captopril, the observation group was treated with felodipine combined with captopril. The efficacy and cardiac function of the two groups were compared. Results The total effective rate in the observation group was higher than that in the control group, and the grading and level of cardiac function in the observation group were better than those in the control group after treatment, with statistical significant (P < 0.05). There was no significant difference in the incidence of adverse reactions such as headache, dizziness, dry cough and gastrointestinal reaction between the two groups (P > 0.05). Conclusion Felodipine combined with captopril has a significant effect on CHF patients, which can significantly improve the grading of cardiac function and restore cardiac function, with good drug safety.