〔Abstract〕 Objective Used PDCA cycle to improve the first aid ability of imaging staff for contrast agent allergic reaction. Methods From October 2020 to December 2020, 22 cases of hospital medical staff in Mengchao Hepatobiliary Hospital of Fujian Medical University were selected as the research object, using the PDCA circulation method combined with imaging simulation exercises, comparing the staff knowledge of the contrast medium, first aid knowledge and first aid simulation exercise score, percent of pass, and other data before and after PDCA cyde method intervention, evaluating the management effect of PDCA cycle method. Results Taking 70 points as the qualifying line, after the implementation of PDCA, the qualified rates of contrast agent knowledge questionnaire, first aid knowledge questionnaire and first aid practice were 86.4 %, 77.3 % and 86.4 % respectively, which were higher than 36.4 %, 45.5% and 27.3 % before PDCA intervention, and the differences were statistically significant (P < 0.05). Conclusion PDCA cycle can effectively improve the first aid ability of imaging staff for contrast agent allergic reaction.