〔Abstract〕 Objective To investigate the accuracy of ultrasound combined with noninvasive prenatal genetic testing (NIPT) in early screening of fetal chromosomal abnormalities. Methods A total of 80 high-risk pregnant women were selected from January 2019 to December 2019 in Korla Hospital of the Second Division of Xinjiang Production and Construction Corps. All pregnant women were tested by ultrasound, NIPT and amniotic fluid karyotype to assess the risk. The results of chromosome karyotype detection in amniotic fluid cells were used as the gold standard to evaluate the diagnostic efficacy of ultrasonography, NIPT and ultrasonography combined with NIPT. Results The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ultrasound combined with NIPT screening were higher than those of ultrasound and NIPT screening alone, and the differences were statistically significant (P < 0.05). Conclusion Ultrasound combined with NIPT in early screening of fetal chromosomal abnormalities has high detection rate and accuracy, and can accurately judge fetal structural malformations and chromosomal abnormalities.