〔Abstract〕 Objective To study the therapeutic effect of Shugan Qingwei method combined with acupoint application on patients with gastroesophageal reflux disease. Methods 120 patients with gastroesophageal reflux disease treated in The Affiliated TCM Hospital of Guangzhou Medical University from February 2019 to February 2021 were randomly divided into control group and observation group, with 60 cases in each group. The control group was treated with western medicine and the observation group was treated with Shugan Qingwei method combined with acupoint application. The clinical effects of the two groups were compared. Results The total effective rate of the observation group was 93.33%, higher than 73.33% of the control group (P < 0.05). After treatment, the clinical symptom scores of the two groups decreased in varying degrees, and the clinical symptom scores of the observation group were lower than those of the control group, and the differences were statistically significant (P < 0.05). After treatment, the gastrin level of the two groups increased in varying degrees, and the level in the observation group was higher than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of pepsinogen I (PG Ⅰ) and PG Ⅱ in the two groups increased to varying degrees, and the levels in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Acupoint application combined with Shugan Qingwei method is effective in the treatment of gastroesophageal reflux disease, which is beneficial to improve the clinical symptoms of patients and increase the levels of gastrin and pepsinogen.