〔Abstract〕 Objective To analyze the efficacy of Bushen Yanggan Huoxue Decoction in the adjuvant treatment of acne vulgaris. Methods A total of 121 patients with acne vulgaris admitted to Guangzhou Institute of Dermatology from May 2019 to March 2021 were divided into a control group (60 cases) and an observation group (61 cases) according to a random number table. The control group was treated with tetracycline tablets combined with vitamin B6, and the observation group was treated with Bushen Yanggan Huoxue Decoction on the basis of the control group. The clinical efficacy, skin physiological indicators and facial recovery of the two groups of patients were observed. Results The total effective rate of the observation group was 91.80%, which was higher than 78.34% of the control group, and the difference was statistically significant (P < 0.05). After treatment, the rate of transepidermal water loss (TEWL) , erythema index (EI), skin color index melanin index (MI), of the observation group were lower than those of the control group and the skin elasticity index (R2) was higher than that of the control group, the differences were statistically significant (P < 0.05). After treatment, the scores of pores, brown spots and facial red areas in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Bushen Yanggan Huoxue Decoction in the adjuvant treatment of acne vulgaris can reduce or eliminate facial skin lesions, improve skin physiological indexes, and then promote facial recovery.