〔Abstract〕 Objective To observe the clinical effect of Chinese medicine wet compress combined with iontophoresis on chemotherapeutic phlebitis. Methods From March 2019 to March 2020, 80 patients with chemotherapeutic phlebitis admitted to the Oncology Department of Jingmen Hospital of Traditional Chinese Medicine were selected and divided into control group and observation group by random number table method, with 40 cases in each group. Patients in the control group were treated with magnesium sulfate wet compress, and patients in the observation group were treated with Chinese Medicine wet compress combined with iontophoresis. The treatment effect, pain relief time, swelling relief time, cure time and coagulation indexes were compared between the two groups. Results The total effective rate of the observation group was 97.5%, which was significantly higher than 72.5% of the control group, the difference was statistically significant (P < 0.05). After treatment, the pain relief time, swelling relief time and phlebitis cure time in the observation group were shorter than those in the control group (P < 0.05). Before treatment, there was no significant difference in various coagulation indexes between the two groups (P > 0.05). After treatment, the levels of D-Dimer (D-D) and fibrinogen (FIB) in the observation group were lower than those in the control group, and the levels of prothrombin time (PT) and activated partial thromboplastin time (APTT) were higher than those in the control group, the differences were statistically significant (P < 0.05). Conclusion The curative effect of Chinese medicine wet compress combined with iontophores is on chemotherapeutic phlebitis is better than traditional treatment.