〔Abstract〕 Objective To study the clinical effect of Zhurong Yikang mixture combined with hyperthermic intraperitoncla perfusion chemotherapy on malignant ascites. Methods A total of 100 patients with malignant ascites caused by malignant tumor admitted to Yingde Hospital of Traditional Chinese Medicine from November 2019 to May 2020 were randomly divided into control group and observation group, with 50 cases in each group. The control group was treated with simple intraperitoneal perfusion chemotherapy, and the observation group was treated with Zhurong Yikang mixture combined with intraperitoneal thermal perfusion chemotherapy. The treatment efficiency, Karnofsky performance status (KPS) score before and after treatment, quality of life improvement after treatment, and adverse reactions during treatment were compared between the two groups. Results The objective remission rate of the observation group was 92%, which was significantly better than 54% of the control group, and the difference was statistically significant (P < 0.05). After treatment, KPS scores in the two groups were significantly higher than that before treatment, and the KPSv score of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05). The improvement rate of quality of life in the observation group was 76%, which was significantly higher than 24% in control group, and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Zhurong Yikang mixture combined with hyperthermic intraperitoneal perfusion chemotherapy has significant efficacy, can effectively improve the health status of patients, and hashigh safety.