〔Abstract〕 Objective To investigate the application value of epinephrine and vasopressin combined cardiopulmonary resuscitation (CPR) in patients with sudden cardiac death. Methods A total of 95 patients with sudden cardiac death admitted to Xiamen Medical Emergency Center from January 2019 to January 2021 were selected as the study subjects, and were divided into control group (47 cases) and observation group (48 cases) according to the treatment plan. Both groups were given CPR, the control group was given epinephrine, and the observation group was given vasopressin in addition to the control group. The efficacy of the two groups was compared. Results The effective rate of cardiopulmonary resuscitation in the observation group was 89.58%, higher than 68.9% in the control group, the difference was statistically significant (P < 0.05). The recovery time of the observation group was shorter than that of the control group, and the difference was statistically significant (P < 0.05). The survival rate of the observation group was 41.67% (20/48), which was higher than that of the control group 19.15% (9/47), and the difference was statistically significant (P < 0.05). There was no significant difference in heart rate between the two groups during CPR, 10 min after CPR and 20 min after CPR (P > 0.05). Conclusion Epinephrine and vasopressin combined cardiopulmonary resuscitation can shorten the resuscitation time and improve the discharge survival rate of patients with sudden cardiac death.