〔Abstract〕 Objective To observe the efficacy of labetalol and phentolamine combined with magnesium sulfate in the treatment of early onset severe preeclampsia (EOSP). Methods A total of 82 patients with EOSP admitted to Quanzhou Hospital of Traditional Chinese Medicine from December 2017 to December 2020 were selected, and they were divided into control group and observation group based on patients' wishes, with 41 cases in each group. The control group was treated with phentolamine combined with magnesium sulfate, and the observation group was treated with labetalol on the basis of the control group. Delivery outcome, [blood pressure (DBP, SBP)], coagulation indexes [(FIB, D-Dimer (D-D), thrombin time (TT), prothrombin time (PT)] before and after treatment in the two groups were observed and compared. Results There were no significant differences in diastolic blood pressure (DBP) and systolic blood pressure (SBP) between the two groups before treatment (P > 0.05). After treatment, SBP and DBP in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05). After treatment, prothrombin time (PT) and thrombin time (TT) in the observation group were higher than those in the control group, while fibrinogen (FIB) and D–Dimer (D-D) were lower than those in the control group, the differences were statistically significant (P < 0.05). The rates of neonatal asphyxia, postpartum hemorrhage and cesarean section in the observation group were lower than those in the control group, with statistical significance (P < 0.05). Conclusion Labetalol and phentolamine combined with magnesium sulfate can reduce blood pressure, improve coagulation function and reduce the incidence of adverse delivery outcomes in PATIENTS with EOSP.