〔Abstract〕 Objective To analyze and study the clinical effects of selected probiotics and low-dose erythromycin treatment in preterm infants with feeding intolerance. Methods 60 cases of feeding intolerance preterm infants who were delivered at the Longyan First Hospital Affiliated to Fujian Medical University from December 2019 to November 2020 and were admitted to the Department of Neonatology were included as the research subjects. They were divided into two groups according to the odd and even number of beds (the odd group was the observation group, and the even group was the control group), each with 30 cases. Both groups of premature infants received conventional treatment. After the feeding intolerance was confirmed, the control group was treated with probiotics alone, and the observation group was treated with low-dose erythromycin. The clinical indicators of the two groups of premature infants were compared to evaluate the clinical treatment efficiency. Results Compared with the control group, the observation group took a shorter time to improve vomiting, abdominal distension and gastric retention, and the difference was statistically significant (P < 0.05); The preterm infants increased their daily milk production, increased body weight, the timeconsuming to achieve total gastrointestinal feeding and the overall treatment effect of the two groups had no statistically significant difference (P > 0.05); During the medication period of the two groups, the laboratory indicators were normal and no related adverse reactions occurred. Conclusion Premature infants with feeding intolerance can choose low-dose erythromycin and probiotics for treatment, but comparing the effects of two drugs, applying with low-dose erythromycin for treatment can quicklyand effectively relieve abdomind distension, gastric retention and vomitting of children.