〔Abstract〕 Objective To investigate the clinical effect of Bushen Yixue Decoction on knee osteoarthritis (KOA). Methods A total of 86 KOA patients admitted to Xiamen Siming Jingyuan Hospital of Traditional Chinese Medicine from January 2020 to December 2020 were selected and divided into observation group and control group according to different treatment regimens, with 43 cases in each group. Both groups were treated with quadriceps femoris functional exercise, the control group was treated with lidocaine hydrochloride combined with triamcinolone acetate, and the observation group was treated with Bushen Yixue Decoction on this basis. The total effective rate, visual analogue scale (VAS) score before and after treatment, knee range of motion (WOMAC) score before and after treatment and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P < 0.05); After 1 and 2 weeks of treatment, the VAS score of the observation group was lower than that of control group, the difference was statistically significant (P < 0.05). After 2 weeks of treatment, the knee motion score in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). There were 2 cases (4.65 %) of gastrointestinal discomfort in the observation group and 3 cases (6.98 %) of edema in the control group, the difference was not statistically significant (P > 0.05). Conclusion Bushen Yixue Decoction can improve the function of knee joint in patients with KOA, with good safety and effective improvement of clinical efficacy, which has high clinical application value.