〔Abstract〕 Objective To explore the effect of Gualouxiebaibanxia Decoction and Wendan Decoction in the treatment of unstable angina pectoris. Methods A total of 97 patients with turbidities and obstructive unstable angina pectoris treated in Sanming Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to October 2020 were randomly divided into observation group (49 cases) and control group (48 cases). The control group received isosorbide mononitrate sustained release tablets, aspirin enteric-coated tablets, clopidogrel tablets, atorvastatin calcium tablets, low molecular weight heparin calcium, sublingual nitroglycerin and other conventional drug treatment. The observation group was treated with traditional Chinese medicine decoction on the basis of conventional drugs, and the therapeutic effects of the two groups were compared. Results After treatment, the weekly dosage of nitroglycerin and the number of attacks per day in the observation group were lower than those in the control group, and the duration of each attack was shorter than that in the control group. The levels of nitric oxide (NO) and prostacyclin (PGI2) were higher than those in the control group, and the level of endothelin-1 (ET-1) was lower than that in the control group. Triglyceride (TG), cholesterol (CHOL), low density lipoprotein cholesterol (LDL-C) were lower than those in the control group, while high density lipoprotein cholesterol (HDL-C) was higher than that in the control group. The effective rate of the observation group was higher than that of the control group. The differences between groups were statistically significant (P < 0.05). Conclusion Conventional medicine combined with Traditional Chinese medicine decoction (Gualouxiebaibanxia Decoction and Wendan Decoction) for the treatment of unstable angina pectoris can reduce the dosage of nitroglycerin and the frequency of attack, improve the clinical indicators and improve the therapeutic effect.