〔Abstract〕 Objective To investigate the clinical efficacy of Qidi Jiangbai Decoction in treating diabetic nephropathy patients with liver and kidney Yin deficiency combined with blood stasis and damp turbidity. Methods A total of 70 diabetic nephropathy patients with liver-kidney Yin deficiency combined with blood stasis and damp turbidity were selected from the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine from October 2019 to July 2020, and they were divided into observation group and control group by random parallel control method, with 35 cases in each group. The control group was treated with benazepril, and the observation group was treated with Qidi Jiangbai Decoction combined with benazepril. The efficacy and renal function indexes [serum creatinine (Scr), urinary microalbumin (umALB), urea ammonia (BUN), 24h Urine protein quantification], Blood lipid indicators [High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triacylglycerol (TG), total cholesterol (TC), glycosylated hemoglobin (HbAlc)] were compared between the two groups. Results The total effective rate of the observation group was 97.14%, higher than 77.14% of the control group, the difference was statistically significant (P < 0.05). There was no significant difference in renal function between the two groups before treatment (P > 0.05). After treatment, renal function of the observation group was better than that of the control group, the difference was statistically significant (P < 0.05). Before treatment, there were no significant difference in HDL-C, LDL-C, TG, TC and HbA1c between the two groups (P > 0.05). After treatment, LDL-C, TG, TC and HbA1c in the observation group were lower than those in the control group, while HDL-C was higher than that of the control group, the differences were statistically significant (P < 0.05). Conclusion Qidi Jiangbai Decoction combined with Benazepril is effective in the treatment of diabetic nephropathy with liverkidney Yin deficiency combined with blood stasis and damp turbidity, which can further improve renal function and regulate blood glucose and lipid.