〔Abstract〕 Objective To analyze the risk factors of cardiovascular disease in elderly patients with coronary heart disease and explore effective treatment methods. Methods 120 patients clearly diagnosed as coronary heart disease admitted to Chongqing Qijiang District People's Hospital from April 2019 to June 2021 were selected and divided into two groups based on the principle of whether cardiovascular disease, observation group with 80 cases were patients with cardiovascular disease, and control group with 40 cases were patients without cardiovascular disease. Risk factors causing cardiovascular disease were analyzed to develop targeted treatment programs. Results The age, gender and low culture level of the two groups had no statistical differences (P > 0.05); Higher fibrin, type 1 diabetes, hypertension, hyperlipidemia, high salt diet, high oil diet and less activity in the observation group were higher than that in the control group, with significant statistical differences (P < 0.05). Logistic multivariate regression analysis showed that elevated fibrin, type 1 diabetes, hypertension, hyperlipidemia, high salt diet, high oil diet, and less activity were risk factors for cardiovascular disease. Conclusion Cardiovascular disease in elderly patients often coincides with type 1 diabetes, hypertension, elevated fibrin, high blood lipid, high salt diet, high oil diet and less activity. Therefore, clinical treatment requires drug control and treatment, and also improves the medication compliance of patients to reduce the probability of cardiovascular events.