〔Abstract〕 Objective To investigate the efficacy and safety of pantoprazole and tiprezone. Methods 100 patients with chronic erosive gastritis treated in Wuchuan People's Hospital from May 2018 to October 2019 were divided into control group and observation group, with 50 cases in each group. The observation group was treated with pantoprazole and teprenone, and the control group was treated with pantoprazole. The indexes of each group were compared. Results After treatment, the level of malondialdehyde (MDA) in the observation group was lower than that in the control group, and the level of prolandin F2α (PGF2α) was higher than that in the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). The total effective rate of the observation group was higher than that of the control group (P < 0.05). Conclusion By using pantoprazole and tiprezone in the treatment of chronic erosive gastritis, it has certain clinical effect and high drug safety.