〔Abstract〕 Objective To analyze the improvement effect of comprehensive treatment on cognitive behavior and motor function in patients with cerebrovascular disease complicated with sleep disorder. Methods A total of 136 patients with cerebrovascular disease admitted to Guangzhou Xinhai Hospital from August 2017 to February 2019 were selected and divided into control group and observation group by random number table method, with 68 cases in each group. The control group was given conventional drug treatment, and the observation group was given comprehensive treatment intervention on the basis of the control group. The sleep quality, cognitive behavior and motor function indexes of the two groups were compared before and after treatment. Results Before treatment, there was no significant difference in sleep quality indexes between the two groups (P > 0.05); After treatment, sleep latency, actual sleep time and awakening times in the observation group were better than those in the control group, the differences were statistically significant (P < 0.05). After treatment, there was no significant difference in the proportion of light sleep (S2) and rapid eye movement (REM) in the observation group compared with the control group (P > 0.05). The proportion of sleeping stage and deep sleep stage (S3/4) was higher than that of the control group, and the difference was statistically significant (P < 0.05). The pittsburgh sleep quality index (PSQI) scores of the observation group was lower than that of the control group at 1 week, 4 weeks and 12 weeks after treatment, and the differences were statistically significant (P < 0.05). After treatment, montreal cognitive assessment scale (MOCA) score and FUGL-Meyer motor function assessment (FMA) score in the observation group were higher than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion Comprehensive treatment intervention can effectively improve the sleep quality, cognitive behavior and motor function of patients with cerebrovascular disease complicated with sleep disorders.