〔Abstract〕 Objective To explore the effect of cardiac resynchronization therapy in patients with congestive heart failure (CHF) and its impact on cardiac function and arrhythmia indicators. Methods A total of 52 CHF patients admitted to Jiamusi Central Hospital from November 2019 to November 2020 were selected and divided into a control group and an observation group according to the random throw method, with 26 cases in each group. The control group was treated with milrinone + metoprolol tartrate injection, and the observation group was treated with a cardiac resynchronization treatment plan. The treatment effects and changes of cardiac function indexes and arrhythmia indexes before and after treatment were compared between the two groups. Results Before treatment, there were no significant difference in left ventricular fractional shortening (LVFS), left ventricular ejection fraction (LVEF), and stroke volume (SV) between the two groups of patients (P > 0.05). After treatment, the LVFS, LVEF, and SV of the observation group were higher than those of the control group, and the difference was statistically significant (P < 0.05); Before treatment, there was no difference in paroxysmal atrial tachycardia, paroxysmal atrial fibrillation and QRS time limit between the two groups of patients statistical significance (P > 0.05). After treatment, the duration of paroxysmal atrial tachycardia, paroxysmal atrial fibrillation and QRS of the observation group were lower than those of the control group, and the difference was statistically significant (P < 0.05). Conclusion Cardiac resynchronization therapy has a significant effect in the treatment of CHF patients.