〔Abstract〕 Objective To study the effect and advantages of clomiphene citrate capsule combined with ethinylestradiol cyproterone tablets in the treatment of polycystic ovary syndrome. Methods 87 patients with polycystic ovary syndrome treated in South Hospital of Fujian Provincial Hospital from January 2017 to January 2020 were selected as the research objects. According to different treatment methods, the patients were divided into control group and observation group. 43 patients treated with metformin combined with clomiphene citrate capsule were included in the control group, and 44 patients treated with ethinylestradiol cyproterone tablets combined with clomiphene citrate capsule were included in the observation group. The ovulation and pregnancy of the two groups were compared and analyzed to study the changes of sex hormone levels in the two groups. Results There was no significant difference in the number of mature follicles and days of ovulation induction between the two groups (P > 0.05); The pregnancy rate and ovulation rate in the observation group were significantly higher than those in the control group (P < 0.05). Before treatment, there was no significant difference in the levels of estradiol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) between the two groups (P > 0.05); After 3 cycles of treatment, the levels of LH and FSH in all patients were significantly lower than those in the same group before treatment, and the levels in the observation group were significantly lower than those in the control group; The E2 levels increased after treatment, and the E2 levels in the observation group was significantly higher than that in the control group (P < 0.05). Conclusion Clomiphene capsule combined with ethinylestradiol cyproterone in the treatment of polycystic ovary syndrome can significantly improve the ovulation rate and pregnancy rate, and has a positive effect on the improvement of sex hormones.