〔Abstract〕 Objective To explore the influencing factors of intracranial hemorrhage in patients with cerebral infarction after thrombolytic therapy. Methods The clinical data of 82 patients with cerebral infarction treated with thrombolytic therapy in Weishi County People's Hospital from February 2019 to January 2021 were analyzed retrospectively, reviewed the baseline data of patients and recorded the baseline data of patients, the occurrence of intracranial hemorrhage 24h after thrombolysis of patients was counted, the related factors that might lead to intracranial hemorrhage after thrombolysis in patients with cerebral infarction were analyzed. Results Intracranial hemorrhage occurred in 15 of 82 patients with cerebral infarction after thrombolysis, the incidence rate was 18.29 % (15/82). The history of atrial fibrillation, fasting blood glucose, interval from onset to thrombolysis, and national institutes of health stroke scale (NIHSS) score in the occurrence group were significantly different from those in the non occurrence group (P < 0.05). The results of Logistic regression analysis showed that history of atrial fibrillation, high fasting blood glucose, long interval from onset to thrombolysis and high NIHSS score at admission were the risk factors of intracranial hemorrhage after thrombolysis in patients with cerebral infarction. Conclusion Intracranial hemorrhage after thrombolytic therapy in patients with cerebral infarction is related to the history of atrial fibrillation, high fasting blood glucose, long interval from onset to thrombolysis and high NIHSS score at admission.