〔Abstract〕 Objective To explore the effect of sodium fructose diphosphate in adjuvant treatment of children's rotavirus enteritis (RVE) and its influence on myocardial injury indicators. Methods A total of 93 children with RVE admitted to Xinglin Branch of the First Affiliated Hospital of Xiamen University from June 2018 to June 2020 were selected and divided into control group (46 cases) and observation group (47 cases) according to random number table method. The control group was treated with Saccharomyces brassi powder, and the observation group was treated with fructose sodium diphosphate on the basis of the control group. The therapeutic effect, myocardial injury indexes and adverse reactions of the two groups were observed. Results The total effective rate of the observation group (93.62%) was higher than that of the control group (76.9%), and the difference was statistically significant (P < 0.05). There were no significant differences in creatine kinase isoenzyme MB (CK-MB), cardiac troponin I (cTnI) and creatine kinase (CK) levels between the two groups before treatment (P > 0.05). After treatment, the levels of CK-MB, cTnI and CK in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the observation group (8.52%) and the control group (13.4%) (P > 0.05). Conclusion Fructose sodium diphosphate assisted treatment of RVE in children can adjust the level of myocardial injury index, improve the therapeutic effect, and do not increase the adverse reactions.