3 野和 5 野调强放疗计划治疗胸段食管癌的剂量学差异
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蒋才慧,女,主治医师,主要研究方向是胸部肿瘤的综合治疗。

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R 735.1

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Dosimetry Difference Between 3-Field IMRT and 5-Field IMRT for Thoracic Esophageal Carcinoma
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    摘要:

    摘 要目的:比较胸段食管癌 3 野和 5 野调强放疗计划治疗的靶区和相关危及器官的剂量学差异。 方法:回顾性分 析泉州市光前医院 2019 年 9 月至 2020 年 8 月收治的胸段食管癌患者 281 例,根据治疗方案不同分为两组,3 野组 146 例 和 5 野组 135 例,3 野组给予 3 野调强计划,5 野组给予 5 野调强计划,比较两种治疗计划的靶区和危及器官的剂量学差 异。 结果:在计划靶区(PTV)1、PTV2 上,两种调强放疗的 Dmax、Dmin、Dmean 上的差异均无统计学意义(P > 0.05), 5 野调强放疗的 D95、V95% 与 CI 高于 3 野调强放疗,HI 低于 3 野调强放疗,差异均具有统计学意义(P < 0.05);5 野调 强放疗的左右肺 V5、V20、V30 高于 3 野调强放疗,差异均具有统计学意义(P < 0.05)。 结论:5 野调强放疗计划的靶区适 形度远高于 3 野调强放疗计划,在大多数患者的应用中具有一定优势。

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    AbstractObjective To compare the dosimetry differences in target volume and associated organs at risk treated with 3-field and 5-field intensity-modulated radiation therapy (IMRT) plans for thoracic esophageal carcinoma. Methods A retrospective analysis was conducted on 281 patients with thoracic esophageal carcinoma admitted to Quanzhou Guangqian Hospital from September 2019 to August 2020. They were divided into two groups according to different treatment regimens: 3-field group (146 cases) and 5-field group (135 cases). Patients in the 3-field group were given a 3-field intensity-modulated plan, while those in the 5-field group were given a 5-field intensity-modulated plan. The dosimetry differences in target volume and organs at risk between the two treatment plans were compared. Results There was no significant differences in Dmax, Dmin and Dmean between the intensity-modulated plans on planning target volume (PTV)1 and PTV2 (P > 0.05). The D95, V95% and CI with 5-field IMRT were higher than those of 3-field IMRT, and the HI was lower than that of 3-field IMRT, the differences were statistically significant (P < 0.05). Moreover, the V5, V20 and V30 of the right and left lungs of the 5-field IMRT were higher than those of 3-field IMRT, and the differences were statistically significant (P < 0.05). Conclusion The conformity of target volume with 5-field IMRT plan performs is much higher than that of 3-field, which has certain advantages in application among most patients.

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  • 收稿日期:2021-09-11
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  • 在线发布日期: 2023-07-14
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