〔Abstract〕 Objective To investigate the effect of radiofrequency thermocoagulation combined with pulsed radiofrequency therapy of dorsal root ganglion on the levels of interleukin-8 (IL-8) and CXC chemokine ligand 10 (CXCL10) in patients with lumbar disc herniation (LDH). Methods 101 patients with LDH treated in Fuzhou Hospital of Traditional Chinese Medicine from February 2020 to January 2021 were selected and divided into observation group and control group according to different treatment methods. There were 60 cases in the observation group and 41 cases in the control group. The control group was treated with radiofrequency thermocoagulation and the observation group was treated with radiofrequency thermocoagulation combined with dorsal root ganglion pulse radiofrequency. The curative effects and the levels of serum IL-8 and CXCL10 before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 93.33%, which was significantly higher than 73.33% of the control group (P < 0.05); After treatment, the levels of IL-8 and CXCL10 in the two groups were lower than those before treatment, while those in the observation group were lower than those in the control group (P < 0.05). Conclusion Radiofrequency thermocoagulation combined with dorsal root ganglion pulsed radiofrequency is effective in the treatment of LDH, and can significantly reduce the levels of serum IL-8 and CXCL10.