〔Abstract〕 Objective To study the efficacy of trimetazidine combined with atorvastatin in the treatment of angina pectoris with dyslipidemia of coronary heart disease. Methods A total of 156 patients with coronary heart disease and angina pectoris treated in Ruijin People's Hospital from June 2019 to June 2020 were selected and randomly divided into two groups, with 78 cases in each group. The control group was treated with trimetazidine, and the observation group was treated with atorvastatin calcium on the basis of the control group, and the treatment effects of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P < 0.05). After treatment, the levels of triglyceride (TG), serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the observation group were lower than those in the control group, while the levels of high density lipoprotein cholesterol (HDL-C) were higher than that in the control group, the differences were statistically significant (P < 0.05). Conclusion Trimetazidine combined with atorvastatin can effectively improve the level of blood lipid in patients with coronary heart disease angina pectoris.