〔Abstract〕 Objective To investigate the clinical value of zinc combined with folic acid in the treatment of diarrhea in children. Methods A total of 100 children with diarrhea admitted to Maternal and Child Health Hospital of Heyuan City from January 2019 to September 2020 were selected as the research objects. According to their treatment plan, all patients were divided into observation group and control group with 50 children in each group. The control group received conventional treatment such as correction of water and electrolyte balance and anti-infection, while the observation group received zinc agent combined with folic acid on the basis of treatment in the control group. The efficacy of both groups were evaluated after 10 days of treatment. The efficacy, diarrhea stop time, stool return to normal time, temperature return to normal time, hospital stay and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of observation group was 94.00 %, higher than 80.00 % of control group, the difference was statistically significant (P < 0.05); The diarrhea stop time, stool return to normal time, temperature return to normal time and hospital stay in observation group were shorter than those in control group, the differences were statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions in two groups (P > 0.05). Conclusion On the basis of conventional treatment, zinc combined with folic acid treatment can effectively improve the symptoms of diarrhea in children and improve the efficacy, and is safe and reliable.